Posts Tagged ‘obesity’

Below are some key points of interest I’ve noted with respect to the article entitled “Fructose, Insulin Resistance, and Metabolic Dyslipidemia”

  • A high flux of fructose to the liver, the main organ capable of metabolizing this simple carbohydrate, perturbs glucose metabolism and glucose uptake pathways, and leads to a significantly enhanced rate of de novo lipogenesis and triglyceride (TG) synthesis, driven by the high flux of glycerol and acyl portions of TG molecules from fructose catabolism.
  • The epidemic of type 2 diabetes is complicated by the fact that it is a multi-factorial disease, frequently associated with a cluster of pathologies including obesity, hypertriglyceridemia, impaired glucose tolerance, and insulin resistance, collectively referred to as the metabolic syndrome (formerly known as syndrome X and insulin resistance syndrome)

Heather Basciano email, Lisa Federico email and Khosrow Adeli email

Clinical Biochemistry Division, Department of Laboratory Medicine and Pathobiology, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

author email corresponding author email

Nutrition & Metabolism 2005, 2:5doi:10.1186/1743-7075-2-5

The electronic version of this article is the complete one and can be found online at:

Received: 15 February 2005
Accepted: 21 February 2005
Published: 21 February 2005

© 2005 Basciano et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Obesity and type 2 diabetes are occurring at epidemic rates in the United States and many parts of the world. The “obesity epidemic” appears to have emerged largely from changes in our diet and reduced physical activity. An important but not well-appreciated dietary change has been the substantial increase in the amount of dietary fructose consumption from high intake of sucrose and high fructose corn syrup, a common sweetener used in the food industry. Read more »